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Systematic surgical assessment of deceased-donor kidneys as a predictor of short-term transplant outcomes

European Surgical Research Sep 09, 2019

Tierie EL, et al. - Via performing this regional prospective pilot study, researchers sought to quantify the impression of the organ procurement surgeon in correlation with the following kidney transplant outcomes: immediate graft function (IGF), delayed graft function (DGF), and primary nonfunction (PNF). Results are compared with factors associated with the 1-year outcome. In this study, they included 90 donors who donated 178 kidneys, of which 166 were transplanted. As per outcomes, different variables influence short-term graft function and 1-year graft function. As per multivariable analysis, the short-term outcomes were significantly related to perfusion quality and kidney width. However as per multivariable analysis of long-term outcomes, the first measured donor creatinine, kidney donor risk index, IGF vs DGF+PNG, and kidney length were predictive of outcomes. Kidneys with poor perfusion and kidneys that were larger had DGF and PNF more frequently. For this, a probable interpretation is that these kidneys might be insufficiently washed out, or even congested, which may predispose to DGF. Reconditioning strategies, such as machine perfusion, may benefit these kidneys most. Decision-making towards allocation and potential reconditioning strategies may be facilitated by a scoring system including these variables.
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