Facciorusso A, et al. - Through a systematic review of multiple databases, the researchers intended to determine the magnitude and kinetics of change in liver stiffness in hepatitis B patients treated with nucleot(s)ide analogs. Before and at least 6 months after starting nucleot(s)ide analogs therapy, they identified twenty-four studies in adults with hepatitis B who underwent transient elastography. Using random-effects meta-analysis, they estimated the change in liver stiffness 6m, 12m, 24m, 36 m and 60 m after starting therapy, as weighted mean difference and 95% confidence interval. It was concluded that antiviral therapy was associated with progressive decline in liver stiffness in patients with hepatitis B, especially in patients with high baseline alanine aminotransferase and viral load.