Shi Z, et al. - Researchers estimated 11 cancer-specific genetic risk score (GRS) (bladder, breast, colorectal, glioma, lung, melanoma, ovarian, pancreatic, prostate, renal, and thyroid cancer) to know their relationship with the respective cancer type, using genotype and phenotype data from The Cancer Genome Atlas (TCGA) and Electronic Medical Records and Genomics (eMERGE). Consistently higher value of mean cancer-specific GRS was recorded in respective cancer cases vs controls for all 11 types of cancer. For 9 types of cancer, significant dose-response relations of higher cancer-specific GRS with higher odds ratio (OR) of an individual type of cancer were obtained when cases were characterized into low-, average-, and high-risk groups based on cancer-specific GRS (<0.5, 0.5-1.5, and >1.5, respectively).