Menza TW, Berry SA, Dombrowski J, et al. - This study unveiled people with HIV (PWH) for whom more frequent syphilis testing and interventions for syphilis prevention may be beneficial.

• Although rates of syphilis among PWH are increasing in the United States, there exists no optimal syphilis screening frequency or prioritization.

• This is a review of all PWH who received care between January 1, 2014 and November 16, 2018 from four sites in the CFAR Network of Integrated Clinical Systems Cohort (CNICS; N=8,455).

• During 29,568 person-years of follow-up, syphilis testing rate was documented to be 118 tests per 100 person-years (95%CI: 117-119).

• The rate of incident syphilis was estimated to be 4.7 cases per 100 person-years (95%CI: 4.5-5.0).

• The observed rates of syphilis diagnosis were identified to be the highest among younger cisgender MSM and transgender females, Hispanic persons, individuals who inject drugs, and those with detectable HIV RNA, rectal infections, and hepatitis C.