Busch A, Jager M, Dittrich F, et al. - This study was attempted to test synovial bone sialoprotein (sBSP) in periprosthetic joint infections (PJI) and aseptic failure (AF) arthroplasty patients before revision surgery. Researchers ascertained sBSP and C-reactive protein (CRP) in synovial fluid samples of PJI (n = 13) patients fulfilling the MSIS criteria and AF (n = 25) patients. Computed statistics ascertained the area under the receiver operating characteristics curve to assess the discrimination ability of the tested synovial markers, beside descriptive analysis and comparison. Considering the MSIS criteria, compared to PJI patients, there were significantly higher sBSP concentrations in synovial fluid samples of AF. synovial C-reactive protein exhibited only fair, sBSP good discrimination potential. The data reveal that sBSP may be considered as an add-on synovial marker, If it is not clear whether PJI is present or not.