Antonell A, Tort-Merino A, Ríos J, et al. - Because synaptic damage, axonal neurodegeneration, and neuroinflammation are common characteristics in Alzheimer disease (AD), frontotemporal dementia (FTD), and Creutzfeldt-Jakob disease (CJD), researchers measured cerebrospinal fluid neurofilament light (NF-L), neurogranin (Ng), 14-3-3, and YKL-40 proteins. The unicentric cohort of 353 candidates involved healthy control (HC) individuals, AD continuum stages, genetic AD and FTD, and FTD and CJD. According to results, biomarkers demonstrated differences in HC individuals compared with AD, FTD, and CJD. The authors discovered that synapse and neurodegeneration biomarkers differentiate HC individuals from neurodegenerative dementias and between AD, FTD, and CJD. When AT(N) system was applied, NF-L and 14-3-3 performed similarly to total tau.