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Sustained vs instantaneous connectivity differentiates cognitive functions of processing speed and episodic memory

Human Brain Mapping Aug 22, 2018

King JB, et al. - Using resting-state functional MRI (fMRI), cognitive, and demographics data from 1,003 subjects included in the Human Connectome Project, researchers proposed a complementary method of analysis by introducing the width of cross-correlation curves between fMRI time series as a metric of the relative duration of synchronous activity between brain regions, or “sustained connectivity”. Particularly in men, sustained connectivity in sensory brain regions was specifically related to differences in processing speed across subjects. It was noted that traditional functional connectivity was associated with a measure of episodic memory, but not with processing speed. The study findings suggested that sustained connectivity might provide new opportunities to study brain dynamics in clinical populations.
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