Kostenniemi UJ, et al. - Researchers assessed the impacts of general infant Hib- and pneumococcal vaccination on invasive infectious diseases among children in this study conducted in a Swedish Arctic region and evaluated the need for meningococcal vaccination. During 1986-2015, in the Västerbotten Region, Sweden, cases of bacterial meningitis and sepsis from diagnosis and laboratory registers were identified. According to results, invasive Haemophilus disease decreased by 89.1%, Haemophilus meningitis decreased by 95.3% and all-cause bacterial meningitis decreased by 82.3% in children 0-4 years of age following general infant Hib vaccination. Invasive pneumococcal disease decreased by 84.7%, pneumococcal meningitis by 67.5% and all-cause bacterial meningitis by 48.0% after pneumococcal vaccination. During the study period, the incidence of invasive meningococcal disease was low. In this Swedish Arctic region, remarkable sustained long-term declines in invasive infectious diseases occurred in younger children following infant Hib and pneumococcal vaccinations. The incidence of invasive meningococcal disease remained low despite not offering general infant meningococcal vaccination.