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Sustained inflation vs standard resuscitation for preterm infants: A systematic review and meta-analysis

JAMA Pediatrics Apr 09, 2020

Foglia EE, te Pas AB, Kirpalani H, et al. - Via performing a systematic review and meta-analysis, researchers investigated effectiveness of sustained inflation vs intermittent positive pressure ventilation and continuous positive airway pressure for the prevention of hospital mortality and morbidity for preterm infants. MEDLINE (through PubMed), Embase, the Cumulative Index of Nursing and Allied Health Literature, and the Cochrane Central Register of Controlled Trials yielded nine studies recruiting 1,406 infants for inclusion in this work. A similar risk of in-hospital mortality was observed in correlation with sustained inflation vs standard therapy. An increased risk of mortality in the first 2 days was observed with sustained inflation vs standard therapy; the risk of any other secondary outcomes was not different. Results thereby provide no support to using sustained inflation after birth to improve outcomes for preterm infants.

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