Peura DA, et al. - Using pooled data from two identical randomized, double-blind, placebo-controlled studies, researchers evaluated esomeprazole 20 mg in the seven-day follow-up period after the two-week treatment period recommended for frequent heartburn. Adults without confirmed diagnoses of gastroesophageal reflux disease experiencing heartburn at least two days/week in the past four weeks received treatment with esomeprazole 20 mg or placebo once daily for 14 days. Observations reveal that the degree of symptom resolution observed during esomeprazole therapy that is consistent with over-the-counter use is associated with the degree of continued symptom relief following the cessation of treatment. Individuals with frequent heartburn, who are likely to self-treat their symptoms without consulting a healthcare provider, displayed sustained therapeutic benefits in association with esomeprazole 20 mg for 14 days, including after the treatment period has ended.