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Susceptibility-weighted imaging in malignant melanoma brain metastasis

Journal of Magnetic Resonance Imaging Sep 26, 2019

Schwarz D, Niederle T, Münch P, et al. - A total of 100 patients with melanoma brain metastases (BM) (69 having received radiotherapy [RT] and 31 RT-naïve) and a control group of 100 melanoma patients without BM were involved retrospectively to systematically investigate the spectrum of intracerebral findings in malignant melanoma (MM) BM on susceptibility-weighted imaging (SWI) and to discover the diagnostic value of SWI. SWI gave little additional diagnostic advantage over standard T1-weighted imaging, as melanin content alone does not lead to diagnostically appropriate SWI blooming. The signal transition of SWI may rather highlight secondary phenomena like microbleeding and/or metal scavenging. Isolated SWI artifacts do not compose vital tumor tissue however it represents unspecific microbleedings, RT-related parenchymal alterations or posttherapeutic remnants of prior metastatic lesions.
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