Ruuth M, et al. - Given that atherosclerotic cardiovascular disease (ASCVD) is caused by low-density lipoprotein (LDL) particles via their retention, modification, and accumulation within the arterial intima, researchers assessed the inherent proclivity of LDL to aggregate upon modification. They determined if there are possible associations between inter-individual differences in this quality and LDL lipid composition and coronary artery disease (CAD) death, and basic mechanisms for plaque growth and destabilization. In the progression of human ASCVD, the susceptibility of LDL to aggregate is a novel measurable and modifiable factor.