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Survival trends in infants undergoing allogeneic hematopoietic cell transplant

JAMA Pediatrics May 09, 2019

Parikh SH, et al. - In this cohort study involving 2,498 infants (a median age of 7 months; range, <1-12 months) who underwent allogeneic hematopoietic cell transplant, researchers analyzed overall survival trends and other outcomes. From 2000 through 2004 to 2005 through 2009, they observed an improvement in survival rates for infants with nonmalignant diseases, and these remained stable thereafter. No improvement in survival was noted from 2000 through 2014 for infants with malignant conditions. Findings suggested that future outcomes may be improved with strategies to lessen relapse and toxicity and to optimize selection of donors and grafts.

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