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Survival patterns of invasive lobular and invasive ductal breast cancer in a large population-based cohort with two decades of follow up

The Breast Jul 26, 2021

Chamalidou C, Fohlin H, Albertsson P, et al. - Because there exists controversy concerning if invasive lobular carcinoma (ILC) has a long-time prognosis different from that of invasive ductal carcinoma (IDC), researchers herein used a large population-based cohort to not only investigate the excess mortality rate ratio (EMRR) of patients with ILC and IDC but also to correlate survival with clinical parameters. They used two Swedish Regional Cancer Registries to select 17,481 patients diagnosed with IDC (n = 14,583) or ILC (n = 2898), younger than 76 years, from 1989 through 2006. They assessed relative survival during 20 years of observation span. A lower EMRR was observed during the first five years post-surgery in patients with ILC vs in patients with IDC, however, during the years 10–15 post-surgery, ILC patients had an increased EMRR relative to patients with IDC. Although these observed EMRR between ILC and IDC were statistically significant, there was a small absolute difference in excess mortality between the two groups.

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