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Survival outcomes of younger patients with mantle cell lymphoma treated in the rituximab era

Journal of Clinical Oncology Feb 21, 2019

Gerson JN, et al. - Researchers retrospectively studied the transplantation-eligible adults age 65 years or younger with newly diagnosed mantle cell lymphoma (MCL) treated between 2000 and 2015 to assess how autologous hematopoietic cell transplantation (AHCT) consolidation influence survival. Collecting data from 25 medical centers for 1,254 patients, they included 1,029 patients. As per propensity score–weighted (PSW) analysis, significantly improved progression-free survival (PFS) but not overall survival was observed with AHCT consolidation after induction. Within the limitations of a retrospective analysis, this study suggests that younger fit patients may benefit in terms of PFS with AHCT consolidation.
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