Xie Z-M et al. – In the current study it was shown that survival outcomes of patients with lobular carcinoma in situ (LCIS) who underwent partial mastectomy without radiotherapy were not inferior to patients who underwent bilateral prophylactic mastectomy.

Methods

• 5964 patients with histologically confirmed LCIS who underwent partial mastectomy alone or bilateral mastectomy were enrolled.

Results

• 208 patients underwent bilateral mastectomy and 5756 patients underwent partial mastectomy alone.
• The 1-, 5- and 10-year estimated overall survival rates were 99.7%, 96.7% and 91.7%, respectively.
• The risk of all-cause mortality in the bilateral mastectomy group did not differ from the partial mastectomy group (HR = 1.106).
• Bilateral mastectomy did not benefit overall mortality (HR = 2.248).
• Patients > 60 years of age had a higher risk of all-cause mortality (HR = 7.593).
• No risk factors, including surgery type, were associated with breast cancer-specific survival.