Ackall FY, Issa K, Barak I, et al. - In this investigation involving 1,074 patients, researchers sought to analyze treatment outcomes in poorly differentiated squamous cell carcinoma (PDSCC) utilizing a large national database. They queried the National Cancer Database for sinonasal invasive SCC, grade 3 (poorly differentiated) from 2004 to 2014. Patient demographics and tumor and treatment features have been tabulated. The most common site was the maxillary sinus (45%). T4 tumors were noted in 50% of patients, with most patients treated at high‐volume facilities (77%). Accordinf to this retrospective database study, sinonasal PDSCC seems to be best treated at high‐volume centers with surgical resection followed by adjuvant radiation. Compared with more differentiated tumors, poorly differentiated grade has worse OS. In patients with positive surgical margins, chemotherapy along with adjuvant radiation can play a role.