Sullivan CB, et al. - In this investigation involving 43 patients (mean age at diagnosis was 74.7 years), researchers characterized outcomes for T3 and T4 cutaneoous squamous cell carcinoma (SCC) of the head or neck treated with surgical resection at one tertiary academic medical center. A retrospective cohort of patients diagnosed with T3 or T4 cutaneous SCC of the head or neck from 2005 to 2016 treated with definitive surgical resection were analyzed. Findings suggested that anatomical subsites tended to have worse overall survival, particularly scalp/neck tumors. Positive final margins tended to show a worse prognosis, and overall survival and recurrence in patients with radical surgical resection were not significantly different vs soft tissue resection. Patients with scalp/neck tumors had a 1-year probability of survival of 85.7%, and the probability of survival was higher than 93% one year after neck dissection.