Bugter O, et al. - Investigators assessed 1,372 candidates to estimate the incidence and survival rate of patients with head and neck squamous cell carcinoma (HNSCC) with multiple primary tumors (MPT) in the HN-region, lung, or esophagus. Of 149 patients, 11% had MPTs in the HN-region, lung, and esophagus. They noticed patients with lung MPTs and esophageal MPTs had significantly worse 5-year survival vs those with HN-MPTs. The 5-year survival rate for candidates with metachronous HN MPT was recorded higher (85%) than for synchronous HN MPTs (25%) indicating a favorable survival for metachronous HN MPT cases.