Yamada K, et al. - Experts coveted an investigation of the clinical outcomes and prognostic factors of submandibular gland carcinoma. Death in the case of submandibular gland carcinoma was primarily attributed to distant metastasis. Findings disclosed that lymph node metastases (≥N2) and tumor grade (high grade) served as the prominent predictors of distant metastasis.

Methods

• A total of 65 patients were recruited for this study.
• The enrollment comprised of patients with submandibular gland carcinoma who underwent initial surgical treatment at the Kyoto University and its affiliated hospitals.

Results

• It was determined that the 3-year overall survival (OS), disease specific survival, locoregional control (LRC), and no distant metastasis (NDM) rates were 74.2%, 74.2%, 90.0%, and 64.8%, respectively.
• Death due to the disease was reported in 16 patients.
• Herein, 5 patients were alive with recurrence, 43 patients were alive without disease and 1 patient died of unrelated disease without recurrence.
• Death cases revealed the development of distant metastasis.
• Tumor grade (high grade) and lymph node metastases (≥N2) served as prominent prognostic factors for OS and LRC, in the univariate analysis.
• Additionally, tumor grade (high grade), T classification (≥T3), and lymph node metastases (≥N2) were discovered to be vital for distant metastasis.
• As illustrated by the multivariate analysis, the following significant prognostic factors were brought to light: Lymph node metastases (≥N2) for OS, LRC, and NDM, and high tumor grade for NDM.