Mantziari S, et al. - Authors planned this study to assess the impact of neoadjuvant treatment upon survival for cT3N0M0 esophageal cancer patients, with subgroup analyses by histological type (squamous cell carcinoma vs adenocarcinoma) and type of neoadjuvant treatment (chemotherapy vs radiochemotherapy). A significant survival benefit was observed with neoadjuvant treatment for clinical T3N0M0 esophageal cancer.