Wang BY, et al. - Researchers analyzed patients with squamous cell carcinoma (SCC) who underwent curative treatment from 2008 to 2014 from the Taiwan Cancer Registry to assess if there is a difference in survival after neoadjuvant chemoradiotherapy plus surgery (CRT-S) compared with definitive chemoradiotherapy (dCRT) in patients with locally advanced oesophageal SCC. They included a total of 5832 patients with clinical stage II and III oesophageal SCC receiving CRT-S (1754) or dCRT (4078). Outcomes suggest better overall survival in correlation with neoadjuvant chemoradiotherapy and oesophagectomy than dCRT among these patients.