Beach JM, et al. - Researchers here aimed at identifying risk factors for mortality after fenestrated and branched endovascular aortic repair (F/B-EVAR) to improve patient selection and facilitate decision making regarding who may benefit from prophylactic F/B-EVAR. They observed the greatest risk of mortality among patients with multiple comorbidities and those undergoing type I or II thoracoabdominal aortic aneurysms (TAAAs) repair; however, in this high-risk population, F/B-EVAR offered greater survival compared with that reported for the natural history of untreated aneurysms. Operative and early mortality were lower than the best-reported open repair outcomes, even in this high-risk population, suggesting a potential benefit in extending the use of F/B-EVAR to low-to-average risk complex aortic aneurysms (CAAs) patients.