Mégraud F, Alix C, Charron P, et al. - In France, surveillance of Helicobacter pylori resistance to antibiotics was conducted in 2014, 2016, and 2018. Researchers here inscribed the outcomes of the 2018 survey and reported the evolution over the 5‐year period. During the year 2018, they conducted this observational study including gastric biopsies obtained from 951 patients by 62 gastroenterologists that were sent to a central laboratory where culture, antimicrobial susceptibility testing, and a real‐time PCR were carried out to detect H pylori and its mutations associated with clarithromycin resistance . Among these patients, H pylori was detected in 359 by both culture and real‐time PCR, and in 7 more by PCR only. For clarithromycin, levofloxacin and metronidazole, primary resistance was 20.9%, 17.6%, and 58.6%, respectively, and secondary resistance was 56.4%, 22.7%, and 87.3%, respectively. Observations revealed relatively stable primary levofloxacin resistance while there was an increase in metronidazole resistance. Interestingly, both naive and treated patients rarely had amoxicillin and rifampicin resistance.