Weber C, Petrov G, Luehr M, et al. - The impact of native valve endocarditis vs prosthetic valve endocarditis on postoperative outcomes and long-term survival was determined. Further, preoperative risk factors were determined in a large cohort of 4,300 patients with infective endocarditis. Researchers conducted a retrospective cohort study in 5 German Cardiac Surgery Centers: the Clinical Multicenter Project of Analysis of Infective Endocarditis in Germany. From 1994 to 2016, they identified 3,143 patients (73.1%) who underwent surgery for native valve endocarditis and 1,157 patients (26.9%) who underwent surgery for prosthetic valve endocarditis. Patients with prosthetic valve endocarditis were older (69 [60-75] vs 63 [52-72] years) and had more comorbidities, such as hypertension (55% vs 46%), diabetes (28% vs 25%), coronary artery disease (32% vs 23%), and preoperative acute kidney injury (41% vs 32%). Outcomes revealed comparable long-term survival for prosthetic valve endocarditis and native valve endocarditis after adjusting for preoperative comorbidities. Thus, this study suggests that for redo operations, prosthetic valve endocarditis alone should not be a contraindication.