Höckel M, Wolf B, Schmidt K, et al. - Carcinoma of the cervix was previously found to spread within ontogenetic cancer fields, so researchers assessed clinical and histopathological data from, the single-center, observational, cohort study, the Leipzig School Mesometrial Resection Study, to find out if locoregional tumor control without adjuvant radiotherapy can be achieved with surgical treatment that accounts for stage-associated, ontogenetic cancer fields and their associated lymphoid tissues. Participants were patients of any age with stage IB1, IB2, IIA1, IIA2, or IIB cervical cancer (according to 2009 International Federation of Gynecology and Obstetrics). These patients underwent total mesometrial resection or extended mesometrial resection and therapeutic lymph node dissection, performed on the basis of ontogenetic cancer fields. Findings revealed that good survival outcomes were achieved in relation to total or extended mesometrial resection with therapeutic lymph node dissection based on ontogenetic cancer fields in patients with cervical cancer. Five-year disease-specific survival was 89.4% and recurrence-free survival was 83.1% in 495 patients with cervical cancer treated with cancer field surgery.