Mastboom MJL, et al. - Patients treated in 31 sarcoma reference centers between January 1, 1990, and December 31, 2017, were evaluated in this study to identify global surgical treatment protocols, and also to assess surgical outcomes, complications, and functional results in patients with diffuse-type tenosynovial giant-cell tumors. A high risk for local recurrent disease and a comparatively high risk for postoperative complications was reported in the surgical treatment of diffuse-type tenosynovial giant cell tumors. The investigators of this study noted surgical complications in 105 participants who had complete data on surgical complications. In what the authors believe to be the largest cohort to date, risk factors for recurrent disease in individual patients had not been identified following surgical treatment in treatment-naive patients.