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Surgical hematoma evacuation vs conservative treatment and functional outcome in cerebellar intracerebral hemorrhage

JAMA Oct 16, 2019

Kuramatsu JB, Biffi A, Gerner ST, et al. - Individual participant data meta-analysis of four observational intracerebral hemorrhages (ICH) studies including 6,580 individuals treated at 64 hospitals across the United States and Germany was analyzed in order to ascertain the relation of surgical hematoma evacuation with clinical outcomes in cerebellar ICH. Amongst 578 with cerebellar ICH, propensity score-matched groups comprised 152 individuals with surgical hematoma evacuation vs 152 individuals with conservative treatment. Following adjustment, surgical hematoma evacuation, compared with conservative treatment, was not significantly related to the probability of superior functional disability at 3 months, however, it was significantly correlated to greater probability of survival at 3 months and at 12 months. A volume range of 12 to 15 cm3 was recognized and below this level, surgical hematoma evacuation was related to a lower probability of the favorable functional outcome, and above, it was correlated with a higher probability of survival. Hence, in individuals with cerebellar ICH, surgical hematoma evacuation, in comparison with conservative treatment, was not related to enhanced functional outcomes. Moreover, the investigation is needed to ascertain whether there are varying relationships on the basis of hematoma volume, provided the null primary outcome.
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