Fahlbusch R, et al. – In this prospective study, clincians aimed to compare primary medical therapy with pituitary surgery in patients with acromegaly. The findings showed that pituitary surgery alone was more effective than primary medical treatment, and the combination of surgery followed by medical therapy was even more effective. Moreover, subjects treated with medical therapy after surgical debulking had a significant enhancement in response rate compared to matched subjects treated with primary medical therapy.