Dahmer MK, Flori H, Sapru A, et al. - Researchers intended to determine if there is an association between plasma surfactant protein D (SP-D) and lung injury in children with acute respiratory failure. The sample consisted of children (aged 2 weeks to 17 years) with acute respiratory failure who took part in the BALI multi-center study. In the analysis, plasma samples were used from 350 patients, 233 patients had a pediatric acute respiratory distress syndrome (PARDS). Multivariable analyses suggested that elevated SP-D levels were correlated with death, duration of mechanical ventilation, PICU length of stay, and highest oxygenation index. According to this prospective cohort study, elevated plasma SP-D levels are linked to severe PARDS and poor outcomes in children with acute respiratory failure. In addition, SP-D levels linked to age.