Saleh NY, Ibrahem RAL, El shafey Soliman S, et al. - This prospective cohort investigation was carried out to determine how surfactant protein D (SP-D) contributes to community-acquired pneumonia severity prediction among pediatric patients. This study included 112 children admitted into wards with pneumonia (simple pneumonia) as well as 68 who were admitted into the Pediatric Intensive Care Unit (PICU) because of severe pneumonia (PICU admitted). Patients with simple pneumonia were found to have significantly lower SP-D level, compared with patients with severe pneumonia. Children with mechanical ventilation, shock, hypoxia, sepsis, and mortality demonstrated the presence of significantly higher SP-D. Overall, findings showed a predictive value of serum SP-D concentration for the detection of severity of community-acquired pneumonia among children.