Iida H, Tani M, Komeda K, et al. - Researchers aimed at examining the predictive value of a novel biomarker incorporating albumin, lymphocytes, and CRP for the prognosis for hepatocellular carcinoma (HCC) after hepatectomy. The discovery cohort comprised 384 patients who underwent hepatectomy in four university hospitals in Japan. They defined the CRP-Albumin-Lymphocyte (CALLY index) as (Albumin×Lymphocyte)/(CRP×10⁴). Comparison of patients with a CALLY index ≥ 5 (n = 200) with those with an index < 5 (n = 184) was performed. In multivariate analysis, the CALLY index was identified as an independent factor of overall survival. Likewise, the 5-year survival rate differed significantly between the CALLY ≥ 5 (73%) and < 5 (48%) groups. The CALLY index was herein suggested to be an independent promising predictive biomarker for postoperative prognosis of patients with HCC.