Carluccio E, et al. - Since in patients with heart failure and reduced ejection fraction (HFrEF), both global right ventricular (RV) longitudinal strain (RVGLS) and free wall RV longitudinal strain (RVFWS) were considered sensitive tools for assessing RV function and for predicting prognosis, researchers compared the prognostic ability of either RV strain parameter in patients with HFrEF, taking into account the degree of LV systolic dysfunction. Speckle-tracking and LV systolic function by global longitudinal strain and LV ejection fraction were evaluated in 288 prospectively enrolled outpatients with stable HFrEF, RVGLS and RVFWS. By C-statistic and net reclassification improvement, prognostic ability was determined. RVFWS is better at predicting outcome in patients with HFrEF, despite the prognostic ability of both RVGLS and RVFWS, mainly because it is less influenced by longitudinal dysfunction with LV.