Bowden P, See AW, So K, et al. - This study was undertaken to investigate outcomes for men with biochemically recurrent prostate cancer who were selected for transponder-guided salvage radiotherapy (SRT) to the prostate bed alone by ⁶⁸ Ga-labelled prostate-specific membrane antigen positron emission tomography (⁶⁸ Ga-PSMA-PET). Researchers conducted a single-arm, prospective study of men with a prostate-specific antigen (PSA) level rising to 0.1–2.5 ng/mL following radical prostatectomy. Researchers screened 92 individuals (median PSA of 0.18 ng/ml, IQR 0.12–0.36) with ⁶⁸ Ga-PSMA-PET and metastatic disease was found in 20 (21.7%) patients. The data demonstrate that pre-SRT ⁶⁸ Ga-PSMA-PET scans detect metastatic disease in a proportion of patients at low PSA levels but fail to improve FFBR. As per the findings, transponder-guided SRT to the prostate bed alone is correlated with a favourable toxicity profile and preserved QoL.