Kesler M, et al. - In this prospective pilot study, researchers evaluated the possible role of ⁶⁸Ga-prostate-specific membrane antigen (PSMA) PET/CT in hepatocellular carcinoma (HCC) imaging. Study participants included 7 patients who had HCC with 41 liver lesions (37 suspected malignant lesions[tumor lesions] and 4 regenerative nodules). According to findings, 36 of the 37 tumor lesions and none of the regenerative nodules exhibited increased ⁶⁸Ga-PSMA uptake, and only 10 lesions were ¹⁸F-FDG–avid. For imaging HCC patients, ⁶⁸Ga- PSMA PET/CT was better than ¹⁸F-FDG PET/CT. Findings suggested that it is more common for HCC lesions to be hypervascular, taking up ⁶⁸Ga-PSMA in tumoral microvessels. For imaging patients with HCC, ⁶⁸Ga-PSMA PET/CT is a possible novel modality.