Guaraldi G, Milic J, Prandini N, et al. - Given molecular imaging with ¹⁸Fluorodeoxyglucose (FDG) and ¹⁸F-sodium-fluoride (NaF) detects arterial inflammation and micro-calcification as well as has the ability to unveil potentially unstable atherosclerotic plaques, so, researchers undertook this study with two clinically similar cohorts of patients living with HIV with no symptomatic cardiovascular disease, in whom, FDG and NaF PET/CT imaging was performed. Findings revealed a higher prevalence of coronary artery uptake with NaF vs FDG both in high and low risk patients, this implies that more sensitivity for detecting coronary atherosclerosis may be yielded by microcalcification imaging vs inflammation imaging. However, a similar uptake of each ¹⁸Fluoride tracer was evident between low and high-risk individuals, which emphasizes the discordance between clinical and imaging-based risk evaluation.