Calais J, Ceci F, Eiber M, et al. - Among patients (older than 18 years of age) with prostate cancer biochemical recurrence postradical prostatectomy and low prostate-specific antigen (PSA) levels (< 2·0 ng/mL), researchers compared prospectively paired ¹⁸F-fluciclovine and prostate-specific membrane antigen (PSMA) PET-CT scans for localising biochemical recurrence in this investigation carried out at University of California Los Angeles (Los Angeles, CA, USA). The eligibility criteria for inclusion were met by 50 patients. Participants were followed up for 8 months (IQR 7–9). The use of PSMA PET-CT scans resulted in higher detection rates, and therefore, this diagnostic modality was recommended when PET-CT imaging is considered for subsequent treatment management decisions in patients with prostate cancer and biochemical recurrence after radical prostatectomy and low PSA concentrations ( ≤ 2·0 ng/mL).