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18F-FDG PET/CT as a noninvasive biomarker for assessing adequacy of treatment and predicting relapse in patients treated for pulmonary tuberculosis

The Journal of Nuclear Medicine Mar 06, 2020

Lawal IO, Fourie BP, Mathebula M, et al. - To evaluate the effect of findings on EOT 18F-FDG PET/CT on tuberculosis relapse in patients treated with a standard regimen of antituberculous treatment (ATT) for drug-sensitive pulmonary tuberculosis (DS-PTB), researchers prospectively included individuals who completed a standard regimen of ATT for DS-PTB and were declared cured based on a negative clinical and bacteriologic examination to undergo EOT 18F-FDG PET/CT. This study included a total of 53 individuals (mean age, 37.81 ± 11.29 y), with 62% being male and 75% HIV-infected. It was noted that a negative EOT 18F-FDG PET/CT result is protective against tuberculosis relapse. The study found that nine percent of individuals with RMA after ATT may experience tuberculosis relapse within 6 mo of completing ATT. Among individuals with tuberculosis relapse, bilateral disease with lung cavitation is prevalent.
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