Chang JJ, et al. – The physicians undertook this study to assess the effects of prehospital sulfonylurea (SFU) use with outcomes in diabetic patients with acute intracerebral hemorrhage (ICH). For improved functional outcome, SFU pretreatment could be an independent predictor in diabetic patients with acute ICH. This relationship needed independent confirmation in a large prospective cohort study.

• A cohort of diabetic patients presenting with acute ICH at a tertiary care center was retrospectively examined.
• Study inclusion criteria included spontaneous ICH etiology and age > 18 years.
• They documented baseline clinical severity using ICH-score. Hematoma volumes (HV) on admission were calculated using ABC/2 formula.
• They documented the unfavorable functional outcome as discharge modified Rankin Scale scores 2-6.

• Inclusion criteria was fulfilled by 230 diabetic patients with acute ICH (mean age 64 ± 13 years, men 53%).
• In 16% of the study population, SFU pretreatment was documented.
• Compared to controls [ICH-score: 1 (IQR: 0-3); HV: 9cm³ (IQR: 3-20)], patients with SFU pretreatment had significantly (p < 0.05) lower median ICH-scores (0, IQR: 0-2) and median admission HV (4cm³, IQR: 1-12).
• In multiple linear regression analyses adjusting for potential confounders, SFU pretreatment was independently (p = 0.033) and negatively correlated with the cubed root of admission HV (linear regression coefficient: -0.208; 95%CI: -0.398 to -0.017).
• In multivariable logistic regression models adjusting for potential confounders, pretreatment with SFU was also independently (p = 0.033) correlated with lower likelihood of unfavorable functional outcome (OR = 0.19; 95%CI: 0.04-0.88).