Rao QW, Zhang SL, Guo MZ, et al. - Researchers investigated the prognostic implications of sulfiredoxin‐1(SRXN1), an antioxidant enzyme, in hepatocellular carcinoma (HCC) patients following partial hepatectomy. They used patients from the public databases and Zhongshan Hospital, to evaluate SRXN1 expression in HCC and normal tissue. HCC samples vs the normal liver tissues exhibited upregulated SRXN1. Shorter survival time was noted in patients with SRXN1 upregulation. A significant correlation of SRXN1 overexpression with advanced clinicopathological parameters was identified. Greater accuracy of the prognostic nomogram based on SRXN1 expression was proved in comparison with routine staging systems for the prediction of overall survival. In protein‐protein interaction network analysis, the first neighbor genes of SRXN1 predominantly were shown to be involved in response to oxidative stress. Overall, experts suggested the possible role of SRXN1 as a prognostic biomarker for the management of HCC.