Fuchs A, et al. - For this study, researchers assessed in patients with severe coronary calcification or stents if subtraction coronary CT angiography (CCTA_sub) decreases the amount of false-positive stenosis evaluations vs conventional coronary CT angiography (CCTA_conv). For this investigation, researchers prospectively enrolled 180 symptomatic patients scheduled for invasive coronary angiography (ICA) and a CT scan (2013-2016) at three international centers. CCTA_sub reduces the false-positive rate in well-aligned, calcified or stent segments thought to have significant stenosis on CCTA_conv in severely calcified coronary arteries or stents. Findings revealed that misregistration artifacts were frequent in CCTA_sub.