Norton DJ, et al. - Subjective memory complaints (SMC) in autosomal dominant Alzheimer's disease (ADAD) were examined in this cross-sectionally study. The authors concluded that cognitively unimpaired PSEN-1 carriers had elevated SMC. While partner- reported SMC increased later in preclinical Alzheimer's disease (AD), closer to clinical onset, self-reported SMC could be a relatively early indicator of preclinical AD.

• For this study, the authors investigated self-reported and study partner-based SMC in 52 young, cognitively unimpaired individuals from a Colombian kindred with early-onset ADAD.
• 26 carried the PSEN-1 E280A mutation, averaging 7 years of age younger than the kindred's expected clinical onset and 26 were age-matched noncarriers.
• Furthermore, participants underwent structural MRI and cognitive testing.

• Compared to noncarriers, self-reported SMC were greater in carriers (p = 0.02).
• Study partner-based SMC did not differ between groups (p = 0.21), however, in carriers increased with age (r = 0.66, p < 0.001) and decreased with hippocampal volume (r = -0.35, p = 0.08).