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Subjective and objective measurements of sinonasal manifestations in patients with autoimmune disorders

The Laryngoscope Apr 29, 2020

Makary CA, Gill B, Parman B, et al. - In this retrospective cohort study, researchers analyzed the subjective and objective measurements of sinonasal manifestations of autoimmune disorders (ADs). For this investigation, they compared all patients with ADs referred to the tertiary care rhinology clinic from 2008 to 2019 with sinonasal symptoms to randomly selected cohorts of noneosinophilic CRS without nasal polyps (neCRSsNP) and eosinophilic CRSsNP (eCRSsNP). Fifty‐three individuals with an AD (26 with sarcoidosis, 14 with systemic lupus erythematosus, 10 with granulomatosis with polyangiitis [GPA], and three with pemphigoid vulgaris) have been identified, and compared with 75 randomly selected neCRSsNP patients and 75 eCRSsNP patients. No significant difference was found in the computed tomography score compared with both groups. Across all four SNOT‐33 subdomains, nasal obstruction, nasal crusting, and epistaxis, patients with an AD have scored significantly lower. Patients with GPA also had the worst symptomatic and endoscopy scores. Compared with patients with CRS without nasal polyps, those with ADs presenting with sinonasal symptoms have a more severe subjective and objective presentation.

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