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Subclinical inflammation and adipose tissue lymphocytes in pregnant females with gestational diabetes mellitus

Journal of Clinical Endocrinology & Metabolism Sep 16, 2020

Cinkajzlová A, Anderlová K, Šimják P, et al. - Researchers conducted this observational study to investigate systemic and local subclinical inflammation and adipose tissue lymphocyte content and phenotype in pregnant women with and without gestational diabetes mellitus (GDM). Participants in the study were 21 pregnant women with GDM (GDM group), 16 pregnant women without GDM (non-GDM group), and 15 nonpregnant control women (N group). In the GDM and non-GDM group, serum samples were taken at 28 to 32 (visit 1 [V1]) and 36 to 38 (V2) gestational weeks and 6 to 12 months after delivery (V3) and before elective gynecological surgery in the N group. Regardless of GDM, pregnant females had higher total lymphocyte count in visceral adipose tissue (VAT) compared with subcutaneous adipose tissue (SAT). GDM was correlated with significant differences in lymphocyte composition between SAT and VAT depots in addition to increased systemic subclinical inflammation.

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