Ho RTH, et al. – This research contemplates the comparative effectiveness of mindfulness and Baduanjin intervention on the bio–psychosocial well–being of people with colorectal cancer. It is expected that candidates in both the mindfulness and Baduanjn intervention group will exhibit better symptomatic management, lower stress level, better mental health, and a higher level of quality of life than the control group. The findings will aid in comprehending the common and unique effectiveness of mindfulness and Baduanjin qigong. The patients and qualified healthcare professionals could opt or provide practices, yielding maximum benefits, satisfaction, adherence and sustainability.