Magri MC, Alvarez MSM, Iogi AA, et al. - In this investigation involving 219 patients with chronic hepatitis C, researchers sought to assess the influence of CXCL9 rs10336, CXCL10 rs3921 and CXCL11 rs4619915 in liver fibrosis when analysed together with PNPLA3 rs738409 and TM6SF2 rs58542926. It was noted that all single nucleotide polymorphisms (SNPs) had a minimum allele frequency > 5%, and CXCL9 rs10336, CXCL10 rs3921 and CXCL11 rs4619915 were in high linkage disequilibrium (D’ ≥ 0.84). The authors observed in the multivariate analysis that male gender, older age, moderate to intense inflammatory activity, moderate to accentuated hepatic steatosis, and the CT genotype of the TM6SF2 rs58542926 SNP had significant associations with advanced fibrosis. Overall, for patients with chronic hepatitis C, the CXCL9 rs10336, CXCL10 rs3921, CXCL11 rs4619915 and PNPLA3 rs738409 SNPs did not impact liver fibrosis.