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Structure/function interrelationships in patients with schizophrenia who have persistent auditory verbal hallucinations: A multimodal MRI study using parallel ICA

Progress in Neuro-Psychopharmacology and Biological Psychiatry Apr 08, 2019

Kubera KM, et al. - In schizophrenia patients with persistent verbal auditory hallucinations (AVH), researchers explored the direct interrelationships between altered structural and functional changes underlying AVH due to the accumulation of neuroimaging evidence for both structural and functional abnormalities. The study sample consisted of 15 schizophrenia patients with AVH, 16 non-hallucinating schizophrenia patients (nAVH), and 19 healthy controls (HC). A significant correlation was found between a structural MRI (sMRI) component and a resting-state functional MRI (rs-fMRI) component, which was significantly different between the group of AVH and non-AVH (nAVH). Two different modality specific rs-fMRI components were related to distinct clinical characteristics. In this analysis, AVH-specific interrelationships between intrinsic network activity and GMV were suggested in conjunction with modality-specific associations with distinct AVH symptom dimensions.
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