Wen MC, et al. - The authors investigated the structural network alterations from healthy aging to prodromal phase of Parkinson's disease (proPD) and to early Parkinson's disease (PD). In the prodromal phase and in early PD, increased network efficiency and connectivity of proPDs and decreased local connectivity of dPDs could suggest the emergence and dissipation of neural compensation, respectively. However, longitudinal studies were required to follow up the long-term structural network changes of proPD patients.