Hu S, et al. - Given that imaging studies have elucidated cerebral changes that may underlie the age-related deficits, researchers ascertained if the structural and functional changes occur in the same brain regions as well as determined whether reduced gray matter volumes (GMV) mediate decreased activation during inhibition. The study sample consisted of 149 participants. It was noted that age was correlated with prolonged stop signal reaction time (SSRT) across study participants. They found that reduction in GMV mediated age-related differences in activations only of the medial prefrontal cortex, providing limited evidence for structure function association. Findings revealed that the decline in inhibitory control, as evidenced in the stop signal task, manifest with both shared and distinct structural and functional processes during aging.