Yun SJ, et al. - Because non-tumor infiltrating inflammatory cells are frequently seen in the stroma of melanoma, researchers studied the role of these stromal inflammatory cells (SIC) in cancer. In 299 subjects with vertical growth phase primary melanomas with at least 10 years of clinical follow-up, the prognostic significance of SIC was evaluated. Investigators found that SIC patients had worse clinical results. Findings revealed that, in melanoma, SIC was related to worse prognosis and the prognostic impact was partially mediated via induction of lymphangiogenesis with increased lymphatic invasion.